Disease&Treatment/Glaucoma1 Steroid-Induced Glaucoma (SIG)?, steroid induced IOP increase 👁 What is Steroid-Induced Glaucoma (SIG)?Steroid-induced glaucoma (SIG) is a form of secondary glaucomacaused by elevated intraocular pressure (IOP) after using steroids,whether topical, periocular, systemic, or injected.🔬 Mechanism of SIGSteroids alter trabecular meshwork structure↑ ECM (extracellular matrix) deposition↓ Phagocytic activity → waste builds up→ Outflow resistance increases → IO.. 2025. 4. 19. Prev 1 Next