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👁 Glaucoma Drugs – α2 Agonists Explained

α2 agonists are a class of glaucoma medications that:
Increase uveoscleral outflow
Reduce aqueous humor production

➡ Core mnemonic: A2 = ↑Outflow + ↓Production


💊 Key Medications

DrugSummary
Apraclonidine Short-term use, post-laser IOP spike, tachyphylaxis common
Brimonidine Long-term use, neuroprotective, available in 0.2% and 0.15%

 

 

 


📊 IOP Reduction Over 3 Months

MedicationMean IOP Drop (mmHg)
Apraclonidine -2.52
Brimonidine -3.59

Brimonidine is preferred for long-term α2 use


✅ Summary

  • α2 agonists are dual-action medications for glaucoma
  • Brimonidine offers added neuroprotection, ideal for NTG
  • Next post: Side effects of brimonidine
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