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Disease&Treatment/Glaucoma
Fixed Combination Drugs, MTMT medically tolerable maximal treatment drugs
eye_doc 2025. 4. 20. 04:33👁 Glaucoma Fixed Combination Eye Drops – Full Overview
Managing glaucoma often requires multiple medications.
However, patient compliance drops as the number of drops increases.
To solve this, fixed combination eye drops have been developed to combine 2 or more active ingredients in one bottle.
💊 Drug Key and Mechanisms
SymbolClassMechanism
| ⓑ | Beta Blockers (BB) | ↓ Aqueous production |
| ⓐ | α2 Agonists | ↓ Production + ↑ Outflow |
| ⓒ | Carbonic Anhydrase Inhibitors (CAI) | ↓ Production |
| ⓟ | Prostaglandin Analogues (PG) | ↑ Uveoscleral outflow |
📦 Key Fixed Combinations
ComboProducts
| ⓑ + ⓒ | Cosopt, Dorz+Timolol, Elazop |
| ⓑ + ⓟ | Xalacom, Duotrav, Ganfort |
| ⓑ + ⓐ | Combigan, Bridin Plus |
| ⓐ + ⓒ | Simbrinza – no BB, unique combo |
✅ Pros and Cons
- Pros
- Improved compliance
- Fewer preservatives
- Cost-effective, convenient
- Cons
- Can’t isolate effective agent
- Side effect source unclear
📌 MTMT Example (Maximum Tolerated Medical Therapy)
- 3-drug: Cosopt + Alphagan-P + Xalatan
- 2-drug: Simbrinza + Xalacom