Acute Posterior Multifocal Plaque-like Pigmented Epithelial Disease (APMPPE) Diagnosis Treatment Prognosis Symptoms Examination

👁 Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE) – Sudden Bilateral Vision Loss in Healthy Adults

APMPPE is a white dot syndrome characterized by
sudden bilateral visual disturbances, often following a viral illness.
The condition is self-limited in most cases, with good visual prognosis,
despite RPE scarring.

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✅ Clinical Summary

FeatureDescription

Age/Sex	20–50 years, M=F
Trigger	URI or viral infection (~30%)
Symptoms	Sudden bilateral blurred vision, photophobia
Fundus	Multiple placoid yellow-white lesions at posterior pole
OCT	Lesions localized to RPE
FAG	Early hypofluorescence → late hyperfluorescence
ICG	Persistent hypofluorescence
Prognosis	Excellent (most recover vision in weeks)
Treatment	Not required in most; steroids if persistent SRF or poor recovery