Diffuse Subretinal Fibrosis (DSF) Fibrosis and Blindness Diagnosis Treatment Prognosis after Acute Retinitis

👁 Diffuse Subretinal Fibrosis (DSF) – A Severe Variant of White Dot Syndrome

DSF is a rare, aggressive form of White Dot Syndrome (WDS)
that causes rapid bilateral subretinal fibrosis,
typically affecting young myopic women.
It can progress to bilateral blindness within weeks.

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✅ Key Clinical Stages

StageSymptoms

Early	Yellow spots, anterior uveitis, vitritis, CME
Mid	Subretinal fluid accumulation
Late	Diffuse fibrotic scarring in posterior & mid-periphery retina
Vision	Severe central vision loss, photophobia

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✅ Imaging Summary

ModalityFinding

Fundus	Yellow-white plaques coalescing into fibrosis
FAG	Hyperfluorescence around fibrotic areas
ICG	Hypofluorescence at lesions
OCT	Subretinal deposits and fibrosis elevation

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✅ Management

• Immediate initiation of high-dose corticosteroids + immunosuppressants (Cyclosporine)
• Fibrosis is irreversible → Early control is critical
• Once fibrosis begins, visual prognosis becomes poor

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✅ Prognosis

• Poor, especially if treatment delayed
• Most patients experience irreversible central vision loss
• Bilateral progression in nearly all cases if untreated