Anti-inflammatory treatment for dry eye syndrome, Cyclosporine A series eye drops, action principle and domestically available products

👁 Cyclosporine Eye Drops for Dry Eye – A Shift Toward Anti-inflammatory Treatment

Dry eye disease is now considered a chronic inflammatory condition,
not merely a tear deficiency. Cyclosporine A (CsA), an immunomodulatory agent,
has emerged as a frontline treatment by suppressing T-cell activity and restoring tear film integrity.

---

✅ How It Works

• Hyperosmolar tears activate antigen-presenting cells → T-cells → cytokine cascade
• CsA suppresses this by:
  • Inhibiting T-cell activation
  • Reducing proinflammatory cytokines
  • Preserving goblet cells and lacrimal glands

---

✅ Key Product Forms

FormNotes

Emulsion	Requires shaking; ex: Restasis, Iporin
Nano-emulsion	No shaking; better absorption; ex: Cyporin-N, Clesier
High-concentration	0.1% formulation, once-daily; ex: Santen’s Ikervis (coming soon)

 

 

 

 

 

 

---

✅ Benefits of Cyclosporine

• Long-term safety established
• Reduces inflammation on ocular surface
• Improves tear production and goblet cell density
• Used for moderate to severe dry eye and post-surgical inflammation

---

✅ Popular Brands in Korea

CategoryExamples

Brand name	Restasis
Nano-form	Cyporin-N, Clesier, Tisporin
Generics	Iporin, Retas, Anaforin, etc.