Gelatinous Drop-like Dystrophy (GDLD) treatment symptom genetics prognosis

👁 What is Gelatinous Drop-like Dystrophy (GDLD)?

Gelatinous Drop-like Dystrophy (GDLD) is a rare inherited corneal dystrophy
characterized by the formation of gelatinous, cyst-like opacities on the corneal surface.

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🔍 Key Features

• Usually appears in early childhood, with mulberry-like elevated lesions beneath the epithelium
• Caused by amyloid protein deposition in the superficial stroma
• Progressive vision loss typically begins before age 20

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🧬 Pathology and Prognosis

• Amyloid accumulates and spreads throughout the cornea
• Corneal transplantation is often required
• However, the disease has a high recurrence rate,
  even after successful transplantation
• Without treatment, total corneal opacity can occur

 

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✅ Summary

• Extremely rare inherited corneal disorder
• Gelatinous, mulberry-like amyloid opacities
• Early-onset vision loss, often requiring corneal transplantation
• High rate of recurrence even after surgery