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Glaucoma drug action mechanism based on autonomic nervous system principle, M agonist alpha1 alpha2 beta2
eye_doc 2025. 4. 20. 03:28👁 Understanding Glaucoma Medications via Autonomic Receptors
The autonomic nervous system regulates intraocular pressure (IOP)
by influencing aqueous outflow and production through various receptors.
💊 Mechanism by Receptor Type
Receptor ActionMechanism of IOP ControlMnemonic
| M3 agonist | Contracts ciliary muscle → ↑Trabecular Outflow | M↑ T↑ |
| α1 agonist | Dilates iris → ↑Trabecular Outflow | A↑ T↑ |
| α1 antagonist | Constricts iris → ↑Uveoscleral Outflow | A↓ U↑ |
| β2 antagonist | ↓Blood flow to ciliary body → ↓Aqueous Production | B↓ P↓ |
| α2 agonist | ↓Aqueous production + ↑Uveoscleral outflow | A2 U↑, P↓ |
✅ Summary
- Most glaucoma drugs work by enhancing outflow or suppressing production
- Understanding autonomic receptor mechanisms helps guide effective treatment
- Next: Breakdown of individual medications by class
