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๐Ÿ‘ What Are Prostaglandin Analogues (PG)?

PG analogues are the most commonly used first-line therapy for
primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG).

โœ… Mechanism of Action

  • Binds to FP receptors in the ciliary muscle
    → Relaxes tissue & remodels ECM
    Increases uveoscleral outflow
    → Lowers intraocular pressure (IOP)

๐Ÿ’Š Common PG Drugs

Drug NameKey Features
Bimatoprost Boosts both uveoscleral & trabecular flow
Latanoprost Widely used; requires refrigeration
Travoprost Stable efficacy, two strengths
Tafluprost Preservative-free, single-dose form
Unoprostone DHA derivative, milder effect

 

 


๐Ÿ“Š 3-Month IOP Reduction (vs. Placebo)

DrugMean IOP Drop (mmHg)
Bimatoprost -5.61
Latanoprost -4.85
Travoprost -4.83
Tafluprost -4.37
Unoprostone -1.91

โœ… PG analogues outperform most other drug classes in lowering IOP
→ Widely used as first-line glaucoma treatment


โœ… Summary

  • PG drops increase outflow rather than reduce production
  • Excellent efficacy with once-daily dosing
  • Bimatoprost shows the strongest IOP reduction

๐Ÿ“Œ Next post: Side effects of PG eye drops

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