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๐Ÿ‘ What is Pseudoexfoliation Syndrome (PEX)?

  • PEX is a systemic ocular condition in which abnormal fibrillar protein deposits accumulate on the lens, iris, cornea, and other ocular structures
  • First described by Lindberg in 1917
  • Best observed after pupillary dilation
  • Predominantly affects elderly patients, more common in females

๐Ÿ” True vs Pseudo Exfoliation

TypeDescription
True exfoliation Capsular delamination after infrared exposure
Pseudoexfoliation Protein debris accumulation on intraocular surfaces

๐Ÿ“Œ Clinical Significance of PEX

1. Increased Risk During Cataract Surgery

FindingRisk
Poor pupil dilation Difficult surgical visualization
Weak zonules Risk of lens subluxation
Thin posterior capsule Higher risk of rupture (PCR)
โžก๏ธ Complication risk up to 5× higher  

 

 

 


2. Glaucoma Association

FactorNote
Glaucoma risk ↑ 10× higher than general population
Accounts for 20–25% of open-angle glaucoma
IOP pattern Higher, more fluctuation
Pathogenesis PEX material blocks aqueous outflow

โžก๏ธ PEX glaucoma is more aggressive and harder to treat


โœ… Summary

  • PEX is a serious condition beyond “debris” — it increases risks in cataract surgery and glaucoma
  • Requires pupillary dilation for diagnosis
  • Needs close monitoring, especially in older adults with poor dilation or suspicious ocular findings
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ยซ   2025/06   ยป
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