Central Cloudy Dystrophy of Francois (CCDF), symptom sign treatment genetics cornea

👁 What is Central Cloudy Dystrophy of Francois (CCDF)?

Central Cloudy Dystrophy of Francois (CCDF) is a rare, inherited corneal condition
first described by the French ophthalmologist Francois, hence its name.

It is characterized by irregular, crocodile shagreen–like opacities in the posterior central corneal stroma.

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🧬 Key Characteristics

• Inherited in an autosomal dominant (AD) pattern
• Often associated with a family history
• Opacities are located in the visual axis, but
• The condition is non-progressive and typically asymptomatic

 

 

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🔍 Diagnosis and Symptoms

• Usually diagnosed incidentally during slit-lamp examination
• Appears as irregular, crocodile skin–like reflections in the center of the cornea
• No vision loss or other symptoms
• No treatment needed unless other conditions are present

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✅ Summary

• Rare, autosomal dominant corneal dystrophy
• Crocodile shagreen–like opacity in the posterior central cornea
• Asymptomatic and non-progressive
• Normal vision, no treatment required