👁 What is Central Cloudy Dystrophy of Francois (CCDF)?
Central Cloudy Dystrophy of Francois (CCDF) is a rare, inherited corneal condition
first described by the French ophthalmologist Francois, hence its name.
It is characterized by irregular, crocodile shagreen–like opacities in the posterior central corneal stroma.
🧬 Key Characteristics
- Inherited in an autosomal dominant (AD) pattern
- Often associated with a family history
- Opacities are located in the visual axis, but
- The condition is non-progressive and typically asymptomatic
🔍 Diagnosis and Symptoms
- Usually diagnosed incidentally during slit-lamp examination
- Appears as irregular, crocodile skin–like reflections in the center of the cornea
- No vision loss or other symptoms
- No treatment needed unless other conditions are present
✅ Summary
- Rare, autosomal dominant corneal dystrophy
- Crocodile shagreen–like opacity in the posterior central cornea
- Asymptomatic and non-progressive
- Normal vision, no treatment required
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