Posterior Amorphous Stromal Dystrophy (PASD), cause treatment genetics onset symptom

👁 What is Posterior Amorphous Stromal Dystrophy (PASD)?

Posterior Amorphous Stromal Dystrophy (PASD) is a rare, inherited corneal condition
characterized by irregular, grayish, wave-like opacities in the posterior corneal stroma.

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🧬 Inheritance and Onset

• Often present at birth or early childhood
• Passed down through autosomal dominant inheritance

 

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🔍 Key Features

• Opacities are limited to the posterior central corneal stroma
• Appear as thin, gray, sheet-like hazes in a non-uniform pattern
• Normal stromal areas remain between the hazy regions
• Affected corneas may become thinner and flatter, causing hyperopia (farsightedness)
• Occasionally associated with iris abnormalities, though visual function is usually preserved

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💊 Is Treatment Needed?

📌 Since vision is typically not significantly affected and the condition is non-progressive,
no treatment is usually required.

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✅ Summary

• Rare, autosomal dominant inherited disorder
• Wave-like stromal opacities in the posterior cornea
• Can cause flattening of the cornea and hyperopia
• Generally harmless, with no need for treatment