Hassall-Henle Body = Descemet warts

👁 What is a Hassall-Henle Body?

Hassall-Henle bodies, also known as Descemet warts, are
protrusions of Descemet’s membrane observed at the peripheral cornea.

They are commonly seen in older individuals and are often considered a non-pathologic, age-related change.

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🔍 Clinical Appearance

• Seen as small, round dark holes under specular microscopy
• Represent thickened peripheral Descemet’s membrane that bulges forward
• Usually asymptomatic and of no clinical concern

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🧬 Difference from Guttata

FeatureHassall-Henle BodyGuttata

Location	Peripheral cornea	Central cornea
Cause	Normal age-related finding	Pathologic (e.g., Fuchs dystrophy)
Appearance	Similar morphology, different context	Similar morphology
Terminology	Peripheral → Hassall-Henle	Central → Guttata

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✅ Summary

• Hassall-Henle body = Descemet wart
• Occurs at the peripheral cornea, not pathological
• Must be differentiated from central guttata,
  which is a marker of endothelial disease