Characteristics, clinical findings, progression pattern, and contact lens-related infection of bacterial keratitis caused by Pseudomonas aeruginosa

Pseudomonas aeruginosa is the most common Gram-negative pathogen responsible for infectious keratitis, especially in contact lens wearers and immunocompromised patients.
Its rapid progression and necrotizing purulent infiltration make early diagnosis and aggressive treatment essential.

🔹 Clinical Features & Progression

• Rapidly progressing stromal melting, with purulent discharge
• May result in ring-shaped stromal infiltrates, Descemetocele, or corneal perforation
• Other pathogens showing similar features: S. pneumoniae, HSV, Acanthamoeba, etc.

🔹 CL-Related Infections

• Bacterial adhesion occurs regardless of contact lens material
• Biofilm formation increases resistance to antibiotics
• Infection can be mild (low virulence organisms) or severe (Pseudomonas)

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📋 Pseudomonas Keratitis Summary Table (English)

CategoryKey Findings

 

Infection Profile	Gram-negative / rapid onset / CL-associated
Hallmark Features	Stromal necrosis, mucopurulent discharge, ring infiltrates
Complications	Descemetocele, perforation, sclerokeratitis
Risk Factors	Contact lenses, immunocompromised, hospitalization, tropics
Differentials	S. pneumoniae, HSV, Acanthamoeba, Klebsiella